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Comparative transcriptome analysis provides insights into the TDG supersaturation stress response of Schizothorax davidi

文献类型： 外文期刊

作者： Chen, Yeyu 1 ; Wu, Xiaoyun 1 ; Liu, Xiaoqing 2 ; Lai, Jiansheng 1 ; Gong, Quan 1 ;

作者机构： 1.Sichuan Acad Agr Sci, Fishery Inst, Chengdu 611730, Peoples R China

2.Xihua Univ, Key Lab Fluid & Power Machinery, Minist Educ, Chengdu 610039, Peoples R China

关键词： Environmental stress; Cell cycle; Apoptosis; Immunity

期刊名称：COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY （ 影响因子：3.9； 五年影响因子：3.8 ）

ISSN： 1532-0456

年卷期： 2023 年 269 卷

页码：

收录情况： SCI

摘要： In the dam discharge season, the supersaturation of total dissolved gas (TDG) in the downstream channel can seriously affect the survival of aquatic organisms. However, few studies have revealed the mechanism by which TDG supersaturation affects the physiology of fish thus far. The present study was conducted to study the mechanism of the effect of TDG supersaturation on Schizothorax davidi, a species that is very sensitive to gas bubble disease. S. davidi was exposed to 116 % TDG supersaturation stress for 24 h. Serum biochemical tests showed that the aspartate aminotransferase and alanine aminotransferase levels after TDG supersaturation exposure were significantly decreased compared to those in the control group, while superoxide dismutase ac-tivity was significantly increased. RNA-Seq of gill tissues identified 1890 differentially expressed genes (DEGs), which consisted of 862 upregulated genes and 1028 downregulated genes, in the TDG supersaturation group vs. the control group. Pathway enrichment analysis revealed that the cell cycle, apoptosis and immune signaling pathways were affected by TDG stress. The results of this study may contribute to our understanding of the underlying molecular mechanism of environmental stress in fish.

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