The Effects of Dietary Supplementation with 25-Hydroxyvitamin D3 on the Antioxidant Capacity and Inflammatory Responses of Pelteobagrus fulvidraco
文献类型： 外文期刊
作者： Liu, Yi 1 ; Xie, Jiang 1 ; Shi, Qingchao 1 ; Gong, Quan 4 ; Qin, Chuanjie 1 ;
作者机构： 1.Neijiang Normal Univ, Key Lab Sichuan Prov Fishes Conservat & Utilizat U, Neijiang 641000, Peoples R China
2.Neijiang Normal Univ, Special Agr Resources Tuojiang River Basin Sharing, Neijiang 641000, Peoples R China
3.Neijiang Normal Univ, Coll Life Sci, Neijiang 641100, Peoples R China
4.Sichuan Acad Agr Sci, Fishery Inst, Chengdu 611731, Peoples R China
关键词： metabolome; transcriptome; yellow catfish; 25(OH)D3; antioxidant; inflammatory
期刊名称：BIOLOGY-BASEL （ 影响因子：3.5； 五年影响因子：4.0 ）
ISSN：
年卷期： 2025 年 14 卷 8 期
页码：
收录情况： SCI
摘要： Based on the limited hepatic hydroxylation efficiency of dietary VD3 in teleosts and the superior bioavailability of its metabolite, 25(OH)D3, this study investigated the regulatory mechanisms of dietary 25(OH)D3 supplementation in yellow catfish-an economically significant species lacking prior nutritional data on this metabolite. A total of 360 fish were divided into three groups-control (basal diet), VD3 (2500 IU/kg VD3), and 25(OH)D3 (2500 IU/kg 25(OH)D3)-and fed for 8 weeks. Compared to the control, both supplemented groups showed elevated superoxide dismutase (SOD), total antioxidant capacity (T-AOC), catalase (CAT), and transforming growth factor-beta (TGF-beta) activities, alongside reduced malondialdehyde (MDA), interleukin-1 beta (IL-1 beta), and tumor necrosis factor-alpha (TNF-alpha) levels. The 25(OH)D3 group exhibited higher T-AOC and CAT activities and lower TNF-alpha than the VD3 group. Metabolomic and transcriptomic analyses identified 65 differentially expressed metabolites (DEMs) and 3515 differentially expressed genes (DEGs). Enrichment analysis indicated that the DEMs (e.g., indole compounds, organic acids, aldosterone, L-kynurenine) and DEGs (pgd, mthfr, nsdhl, nox5, prdx2, mpx, itih2, itih3, eprs1) that were highly and significantly expressed in the 25(OH)D3 group were primarily associated with antioxidant defense and inflammatory responses. Dietary 25(OH)D3 was more effective than VD3 in promoting antioxidant capacity and modulating inflammation in yellow catfish.
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