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Magnetic-gold nanoparticle-mediated paper-based biosensor for highly sensitive colorimetric detection of food adulteration

文献类型： 外文期刊

作者： Wang, Anyu 1 ; Chen, Zihan 1 ; Feng, Xiao 2 ; He, Guangyun 3 ; Zhong, Tian 1 ; Xiao, Ying 1 ; Yu, Xi 1 ;

作者机构： 1.Macau Univ Sci & Technol, Fac Med, Ave Wai Long, Taipa, Macao, Peoples R China

2.Nanjing Univ Finance & Econ, Coll Food Sci & Engn, Collaborat Innovat Ctr Modern Grain Circulat & Saf, Key Lab Grains & Oils Qual Control & Proc, Nanjing, Peoples R China

3.Sichuan Acad Agr Sci, Inst Qual Stand & Testing Technol Agroprod, Chengdu 610066, Peoples R China

关键词： Small-scale equipment; Visualized detection; Colorimetric reaction; DNA enrichment; Digital analysis

期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：12.2； 五年影响因子：11.9 ）

ISSN： 0304-3894

年卷期： 2024 年 475 卷

页码：

收录情况： SCI

摘要： Food adulteration presents a significant challenge due to the evasion of legal oversight and the difficulty of identification. Addressing this issue, there is an urgent need for on-site, rapid, visually based small-scale equipment, along with large-scale screening technology, to enable prompt results without providing opportunities for dishonest traders to react. Colorimetric reactions offer advantages in terms of speed, visualization, and miniaturization. However, there is a scarcity of suitable colorimetric reactions for food adulteration detection, and interference from colored food impurities and easily comparable color results affects accuracy. To overcome limitations, this study introduces a novel approach utilizing polydopamine magnetic nanoparticles to enrich DNA in food samples, effectively eliminating interfering components. By employing gold nanoparticles to generate magnetic-gold nanoparticles, a single magnetic bead achieves simultaneous enrichment, impurity removal, and detection. The use of paper-based biosensors and visualization equipment allows for the visualization and digital analysis of results, achieving a low detection limit of 4.59 nmol mL-1. The method also exhibits high accuracy and repeatability, with a RSD ranging from 1.6 % to 4.0 %. This innovative colorimetric method addresses the need for rapid, miniaturized, and large-scale detection, thus providing a solution for food adulteration challenges.

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