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A preliminary study of combined toxicity and underlying mechanisms of imidacloprid and cadmium coexposure using a multiomics integration approach

文献类型： 外文期刊

作者： Wang, Yuankai 1 ; Zhuang, Ziyue 1 ; He, Guangyun 7 ; Zalan, Zsolt 4 ; Shi, Hui 1 ; Du, Muying 1 ; Kan, Jianquan 1 ; Cai, Tian 2 ; Chen, Kewei 1 ;

作者机构： 1.Southwest Univ, Coll Food Sci, 2 Tiansheng Rd, Chongqing 400715, Peoples R China

2.Southwest Univ, Sch Chem & Chem Engn, 2 Tiansheng Rd, Chongqing 400715, Peoples R China

3.Chinese Hungarian Cooperat Res Ctr Food Sci, Chongqing 400715, Peoples R China

4.Hungarian Univ Agr & Life Sci, Inst Food Sci & Technol, Buda Campus,Villany Str 29-43, H-1118 Budapest, Hungary

5.Minist Agr & Rural Affairs Peoples Republ China, Lab Qual & Safety Risk Assessment Agroprod Storage, Chongqing 400715, Peoples R China

6.Chongqing Key Lab Specialty Food Cobuilt Sichuan &, Chongqing 400715, Peoples R China

7.Sichuan Acad Agr Sci, Inst Qual Stand & Testing Technol Agroprod, Chengdu 610066, Peoples R China

关键词： Imidacloprid; Cadmium; Combined toxicity; Untargeted metabolomics; Transcriptomics; Oxidative stress

期刊名称：TOXICOLOGY （ 影响因子：4.6； 五年影响因子：4.8 ）

ISSN： 0300-483X

年卷期： 2025 年 511 卷

页码：

收录情况： SCI

摘要： Imidacloprid (IMI) and cadmium (Cd) have been shown to be harmful to mammals separately, but their combined toxicity to mammals remains largely unknown. In this study, biochemical analysis (oxidative stress and serum indicators of liver and kidney function), pathological sections and multiomics (metabolomics and transcriptomics) methods were used to investigate the changes and mechanisms of liver and kidney in mice coexposed to IMI and Cd. Biochemical analysis and pathological section results showed that oxidative stress, organ function, and cell damage were aggravated after the combination of the two methods. Omics results revealed the following mechanism: When mouse liver and kidney cells were threatened by the external environment, mitochondrial DNA was inhibited, which leads to changes in energy metabolism. In this process, lipid metabolism and amino acid metabolism were disordered, resulting in the inhibition of substances related to lipid metabolism and amino acid metabolism that protect the body from oxidative damage, and then showed more serious liver and kidney oxidative stress and liver and kidney function and cell damage. This research offers novel insights for the assessment of the safety profile associated with the concurrent exposure of the two chemicals in mammalian species.

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