Preparation of a novel brain-targeted EGCG liposome and its antioxidative neuroprotection
文献类型： 外文期刊
作者： Xia, Chen 1 ; Liu, Gang 3 ; Zhao, Jiayuan 3 ; Wang, Siqi 2 ; Yang, Chunyan 2 ; Zhu, Yongqing 1 ; Deng, Junlin 1 ; Xiang, Zuoya 1 ; Yu, Manyou 1 ; Guo, Yi 1 ; Wu, Yong 2 ; Chen, Jian 1 ;
作者机构： 1.Sichuan Acad Agr Sci, Inst Agroprod Proc Sci & Technol, Inst Food Nutr & Hlth, Chengdu 610066, Peoples R China
2.Sichuan Univ, West China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst, Educ Minist,Dept Med Chem, Chengdu 610041, Peoples R China
3.Sichuan Normal Univ, Coll Life Sci, Chengdu 610101, Sichuan, Peoples R China
关键词： EGCG; Glucose-modified liposomes; Brain targeting; Antioxidant; Neuroprotection
期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：5.6； 五年影响因子：5.3 ）
ISSN： 1756-4646
年卷期： 2023 年 111 卷
页码：
收录情况： SCI
摘要： (-)-Epigallocatechin-3-gallate (EGCG) possesses potent antioxidant and neuroprotective properties. In this study, a novel glucose-modified EGCG encapsulated liposome (EGCG-Glu-Lip) was developed and characterized. EGCGGlu-Lip liposome's cytotoxicity, brain targeting ability, and its antioxidative neuroprotection were examined via bEnd.3 and PC12 cells testing. EGCG-Glu-Lip liposome particle mean size was 158.7 nm, with encapsulation efficiency 73.05 % under EGCG/lipid mass ratio 1:22 and soybean phospholipids (SPC) to cholesterol (Chol) mass ratio 3.84:1. EGCG-Glu-Lip exhibited less cytotoxicity, stronger protection to PC12 cells from H2O2 induced oxidative damage, keeping reactive oxygen species (ROS) level. Glucose modified liposome (Glu-Lip) cellular uptake in bEnd.3 and PC12 cells were 1.5-fold and 1.3-fold higher than that of Lip, supporting EGCG-Glu-Lip possessing enhanced blood-brain barrier (BBB) permeability mediated via glucose transporter protein 1 (GLUT1) and neuronal cell uptake for brain targeting. EGCG-Glu-Lip could provide an efficient nano delivery pathway to deliver sufficient EGCG to brain tissue exerting its antioxidative neuroprotection more efficiently.
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