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Chitosan-zein-icariin complexes modulate double emulsion phase transitions to potentiate absorption efficiency

文献类型： 外文期刊

作者： Shen, Yifeng 1 ; Fang, Chunyan 2 ; Huang, Xiaopeng 1 ; Zhang, Jingyi 1 ; Zhu, Junlong 1 ; Zhu, Kun 1 ; You, Yaodong 1 ; Yang, Dongdong 3 ;

作者机构： 1.Hosp Chengdu Univ Tradit Chinese Med, TCM Regulating Metab Dis Key Lab Sichuan Prov, Chengdu 610032, Peoples R China

2.Sichuan Acad Agr Sci, Inst Qual Stand & Testing Technol Agroprod, Chengdu 610066, Peoples R China

3.Hosp Chengdu Univ Tradit Chinese Med, Dept Neurol, Chengdu 610032, Peoples R China

关键词： Icariin; Ternary complex; Double emulsion; Bio-accessibility

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.5； 五年影响因子：8.7 ）

ISSN： 0141-8130

年卷期： 2025 年 287 卷

页码：

收录情况： SCI

摘要： This study developed a chitosan-zein-icariin ternary complex through reversed-phase precipitation to stabilize double emulsions using one-step emulsification method. Results indicated that icariin and chitosan-zein formed spherical microstructures via the rearrangement of hydrogen bonding networks and hydrophobic interactions. All complexes exhibited pale-yellow color and demonstrated single and uniform size distribution. The thermal stability and interfacial contact angle of the complexes significantly decreased with the incorporation of icariin. The prepared double emulsion microstructures displayed multi-chambered configurations due to polarity differences, solidifying during cold storage as a result of phase shifts in coconut oil, which led to an increased storage modulus. While the double emulsion microstructure showed enhanced storage stability, droplet size increased markedly when subjected to NaCl and temperature variations. Following in-vitro digestion, the double emulsion microstructure disintegrated; average particle size decreased, resulting in the release of icariin from the ternary complex during intestinal phases, thereby enhancing bioaccessibility. Furthermore, it was observed that icariin within the ternary complex influenced absorption efficacy based on its concentration levels, as evidenced by Caco-2 cell studies, though this effect was greater than that observed for the zein-icariin binary complex. The results of this study provide a theoretical foundation for efficient delivery systems involving hydrophobic multivariate complexes.

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