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Dissolving microneedles: Drug delivery and disease treatment

文献类型： 外文期刊

作者： Zhuo, Yanling 1 ; Wang, Fangyue 3 ; Lv, Qizhuang 2 ; Fang, Chunyan 5 ;

作者机构： 1.Hunan Agr Univ, Coll Vet Med, Changsha 410128, Peoples R China

2.Yulin Normal Univ, Coll Intelligent Agr, Yulin 537000, Peoples R China

3.Chengdu Univ Tradit Chinese Med, Chengdu 610072, Peoples R China

4.Guangxi Key Lab Agr Resources Chem & Biotechnol, Yulin 537000, Peoples R China

5.Sichuan Acad Agr Sci, Inst Qual Stand & Testing Technol Agroprod, Chengdu 610066, Peoples R China

关键词： Dissolving microneedles; Drug delivery; Disease treatment; Application

期刊名称：COLLOIDS AND SURFACES B-BIOINTERFACES （ 影响因子：5.6； 五年影响因子：5.4 ）

ISSN： 0927-7765

年卷期： 2025 年 250 卷

页码：

收录情况： SCI

摘要： Traditional transdermal drug delivery methods are often plagued by technical inefficiencies, limited absorption, and the potential for adverse reactions. In contrast, dissolving microneedles (DMNs) offer a novel approach to transdermal drug delivery by effectively merging the benefits of subcutaneous injection with those of conventional transdermal methods. These microneedles dissolve completely within the body, releasing the encapsulated antigen without leaving any sharp remnants. Furthermore, DMNs overcome the limitations of traditional transdermal patches, which are restricted to delivering only small molecule drugs. By facilitating the efficient transdermal absorption of large molecules, DMNs enable precise and painless disease treatment. With advantages such as effective delivery, safety, controllable administration, DMNs hold significant promise in the fields of disease treatment and drug delivery. This article explores the substrate materials, preparation techniques, characterization methods, and current applications of DMNs. We also discuss the current challenges and obstacles faced by DMNs. Finally, we outline potential future research directions for DMNs, aiming to provide a theoretical reference for researchers involved in their preparation and application.

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