Purification of Phenolic Compounds from Camellia polyodonta Flower: Composition Analysis, Antioxidant Property, and Hypolipidemic Activity In Vitro and In Vivo
文献类型： 外文期刊
作者： Xiang, Zhuoya 1 ; Liu, Li 1 ; Xu, Zhou 3 ; Kong, Qingbo 1 ; Liang, Heng 1 ; Feng, Shiling 1 ; Chen, Tao 1 ; Zhou, Lijun 1 ; Yang, Hongyu 1 ; Ding, Chunbang 1 ;
作者机构： 1.Sichuan Agr Univ, Coll Life Sci, Yaan 625014, Peoples R China
2.Sichuan Acad Agr Sci, Inst Agroprod Proc Sci & Technol, Inst Food Nutr & Hlth, 60 Shizishan Rd, Chengdu 610066, Peoples R China
3.Xichang Univ, Panxi Crops Res & Utilizat Key Lab Sichuan Prov, Xichang 615000, Peoples R China
关键词： Camellia polyodonta flower; phenolic compounds; purification; antioxidant activity; hypolipidemic activity
期刊名称：ANTIOXIDANTS （ 影响因子：6.0； 五年影响因子：6.7 ）
ISSN：
年卷期： 2024 年 13 卷 6 期
页码：
收录情况： SCI
摘要： Camellia polyodonta flowers are rich sources of phenolics and less attention has been paid to their potential biological activity. This study aims to explore the crude extracts and resulting purified fractions (CPFP-I, II, III, and IV) through compositional analysis and antioxidant and hypolipidemic activities in vitro and in vivo. Among four fractions, CPFP-II contained the highest total phenolic content and flavonoid content, while CPFP-III exhibited the greatest total proanthocyanidin content. Among the 14 phenolic compounds, CPFP-II displayed the highest content of procyanidin B2, B4, and C1, whereas CPFP-III contained the highest amount of 1,2,3,6-tetragalloylglucose. The DPPH, ABTS, and FRAP assessments demonstrated a consistent trend: CPFP-II > CPFP-III > CPFP-I > CPFP-IV. In vivo experiments showed that that all four fractions significantly reduced lipid levels in hyperlipidemic C. elegans (p < 0.05), with CPFP-II exhibiting the most potent effect. Furthermore, CPFP-II effectively bound to bile acids and inhibited the enzymatic activity of pancreatic lipase in vitro. Consequently, CPFP-II should be prioritized as a promising fraction for further exploration and should provide substantial support for the feasibility of the C. polyodonta flower as a natural alternative.
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