Liver Transcriptome Analysis Reveals Energy Regulation and Functional Impairment of Onychostoma sima During Starvation
文献类型： 外文期刊
作者： Chen, Chunna 1 ; Zhou, Bo 1 ; Lin, Jue 1 ; Gong, Quan 1 ; Xu, Fei 1 ; Li, Zhengyi 1 ; Huang, Yingying 1 ;
作者机构： 1.Sichuan Acad Agr Sci, Fishery Inst, Chengdu 611731, Sichuan, Peoples R China
关键词： Starvation; Liver; Comparative transcriptome; Energy metabolism; Antioxidant defenses; Immune response; Onychostoma sima
期刊名称：MARINE BIOTECHNOLOGY （ 影响因子：3.0； 五年影响因子：3.4 ）
ISSN： 1436-2228
年卷期： 2023 年 25 卷 2 期
页码：
收录情况： SCI
摘要： Releasing juvenile fish into resource-depleted waters is regarded as an effective way to restore fishery resources. However, during this stage, released fish are most vulnerable to long-term food deprivation due to environmental changes and low adaptability. Therefore, research regarding the energy regulation of fish under starvation stress is crucial to the optimization of release strategies. In this study, we performed a transcriptome analysis of the liver of Onychostomasima subjected to starvation for 14 days. The results showed that, under long-term starvation, the liver regulated glucose homeostasis by activating the gluconeogenesis pathway. Meanwhile, the fatty acid metabolism pathway was activated to supply acetyl-coA to the TCA cycle, thus increasing mitochondrial ATP production and maintaining the balance of energy metabolism. Nevertheless, the activation of energy metabolism could not completely compensate for the role of exogenous nutrients, as evidenced by the downregulation of many genes involved in antioxidant defenses (e.g., cat, gpx3, mgst1, and mgst2) and immune response (e.g., c3, cd22, trnfrsf14, and a2ml). In summary, our data reveal the effects of long-term starvation on the energy metabolism and defensive regulation of starved juvenile fish, and these findings will provide important reference for the optimization of artificial release.
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