文献类型： 外文期刊
作者： Liu, Li 1 ; Zhou, Jiasi 1 ; Xu, Zhou 2 ; Kong, Qingbo 1 ; Zhang, Jie 1 ; Wang, Heng 1 ; Xiang, Zhuoya 1 ; Chen, Tao 1 ; Zhou, Lijun 1 ; Feng, Shiling 1 ; Yang, Hongyu 1 ; Huang, Yan 1 ; Ding, Chunbang 1 ;
作者机构： 1.Sichuan Agr Univ, Coll Life Sci, Yaan 625014, Peoples R China
2.Xichang Univ, Panxi Crops Res & Utilizat Key Lab Sichuan Prov, Xichang 615000, Peoples R China
3.Sichuan Acad Agr Sci, Inst Agroprod Proc Sci & Technol, Chengdu 610066, Peoples R China
关键词： Camellia oleifera oil; Caenorhabditis elegans; Lifespan; Transcriptomics; Metabolomics
期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：5.6； 五年影响因子：5.3 ）
ISSN： 1756-4646
年卷期： 2023 年 110 卷
页码：
收录情况： SCI
摘要： Aging is a major international concern that brings formidable socioeconomic and healthcare challenges. Therefore, this study aimed to investigate the positive effect of Camellia oleifera oil (CO) on the lifespan of C. elegans through transcriptome and metabolome analysis. The results demonstrated that CO direct significantly increased the lifespan and mean lifespan to 25.00 and 18.43 d, respectively, compared to the control group (15.95 d). Moreover, CO supplementation significantly improved the healthspan of C. elegans. Additionally, CO altered the transcription levels of genes involved in longevity regulating pathway and activated stress resistance pathway and influenced the levels of metabolic biomarkers related to galactose metabolism. Additionally, CO significantly reduced the content of ROS and MDA in C. elegans by 21.54% and 42.40%, respectively. Together, the study highlights the potential of CO in promoting lifespan and improving the health status, which shall facilitate its further development in the food and pharmaceutical industries.
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