Genome-wide analysis of deletions in maize population reveals abundant genetic diversity and functional impact
文献类型： 外文期刊
作者： Zhang, Xiao 1 ; Zhu, Yonghui 4 ; Kremling, Karl A. G. 3 ; Romay, M. Cinta 3 ; Bukowski, Robert 5 ; Sun, Qi 5 ; Gao, Sh 1 ;
作者机构： 1.Sichuan Agr Univ, Maize Res Inst, Chengdu, Sichuan, Peoples R China
2.Minist Agr, Key Lab Biol & Genet Improvement Maize Southwest, Chengdu, Sichuan, Peoples R China
3.Cornell Univ, Inst Genom Divers, 175 Biotechnol Bldg, Ithaca, NY 14853 USA
4.Sichuan Acad Agr Sci, Crop Res Inst, Chengdu, Sichuan, Peoples R China
5.Cornell Univ, Inst Biotechnol, Bioinformat Facil, Ithaca, NY USA
6.Cornell Univ, ARS, USDA, RW Holley Ctr, Ithaca, NY USA
7.Chinese Acad Sci, Innovat Acad Seed Design, Inst Genet & Dev Biol, State Key Lab Plant Cell & Chromosome Engn, Beijing, Peoples R China
8.Chinese Acad Sci, Inst Genet & Dev Biol, CAS JIC Ctr Excellence Plant & Microbial Sci CEPA, Beijing, Peoples R China
9.Univ Chinese Acad Sci, Beijing, Peoples R China
期刊名称：THEORETICAL AND APPLIED GENETICS （ 影响因子：5.699； 五年影响因子：5.565 ）
ISSN： 0040-5752
年卷期：
页码：
收录情况： SCI
摘要： Key message Two read depth methods were jointly used in next-generation sequencing data to identify deletions in maize population. GWAS by deletions were analyzed for gene expression pattern and classical traits, respectively. Many studies have confirmed that structural variation (SV) is pervasive throughout the maize genome. Deletion is one type of SV that may impact gene expression and cause phenotypic changes in quantitative traits. In this study, two read count approaches were used to analyze the deletions in the whole-genome sequencing data of 270 maize inbred lines. A total of 19,754 deletion windows overlapped 12,751 genes, which were unevenly distributed across the genome. The deletions explained population structure well and correlated with genomic features. The deletion proportion of genes was determined to be negatively correlated with its expression. The detection of gene expression quantitative trait loci (eQTL) indicated that local eQTL were fewer but had larger effects than distant ones. The common associated genes were related to basic metabolic processes, whereas unique associated genes with eQTL played a role in the stress or stimulus responses in multiple tissues. Compared with the eQTL detected by SNPs derived from the same sequencing data, 89.4% of the associated genes could be detected by both markers. The effect of top eQTL detected by SNPs was usually larger than that detected by deletions for the same gene. A genome-wide association study (GWAS) on flowering time and plant height illustrated that only a few loci could be consistently captured by SNPs, suggesting that combining deletion and SNP for GWAS was an excellent strategy to dissect trait architecture. Our findings will provide insights into characteristic and biological function of genome-wide deletions in maize.
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