文献类型： 外文期刊
作者： Li, Minghan 1 ; Li, Wei 2 ; Xiao, Yicen 2 ; Liu, Qianshan 2 ; Liang, Liyuan 2 ; Wang, Deqiang 2 ; Huang, Wenli 4 ; Wang, Liang 2 ;
作者机构： 1.Chongqing Univ Posts & Telecommun, Sch Optoelect Engn, Chongqing 400065, Peoples R China
2.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China
3.Univ Chinese Acad Sci, Chongqing Sch, Chongqing 400714, Peoples R China
4.Sichuan Acad Agr Sci, Biotechnol & Nucl Technol Res Inst, Chengdu 610066, Peoples R China
5.Chongqing Key Lab Intelligent Med Engn Hepatopanc, Chongqing 401147, Peoples R China
关键词： HIV-1 protease; GagPol precursor; Enzyme inactivation; Co-60 gamma-radiation; Nanopore
期刊名称：BIOSENSORS & BIOELECTRONICS （ 影响因子：12.545； 五年影响因子：10.722 ）
ISSN： 0956-5663
年卷期： 2021 年 194 卷
页码：
收录情况： SCI
摘要： Inhibition of HIV-1 protease (PR) activity is realized by exposure to Co-60 gamma-radiation. The radiation effects on enzyme kinetics of HIV-1 PR are subsequently monitored using nanopore sensor. Substantial loss of proteolytic efficiency towards GagPol polypeptide is observed due to the radiation treatment. Results shows similar to 50% of GagPol polypeptide was not involved in HIV-1 PR proteolysis by exposure to ultra-low intensity of gamma-radiation (0.1K Gy), and the values reach to over 90% with high gamma-ray treatment. Besides, the inactivation effect is also verified in blood samples which contain the virus protease. Our finding provides the potential benefits of gamma-radiation to inactivate viral proteinic function, and might be a complementary to the designation of HIV-1 PR inhibitors.
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