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Advances in militarine: Pharmacology, synthesis, molecular regulation and regulatory mechanisms

文献类型： 外文期刊

作者： Jia, Xueyan 1 ; Li, Qingqing 1 ; Xu, Mengwei 1 ; Zhang, Jie 3 ; Xu, Delin 1 ;

作者机构： 1.Zunyi Med Univ, Dept Cell Biol, Zunyi 563099, Peoples R China

2.Zunyi Med Univ, Dept Med Instrumental Anal, Zunyi 563099, Peoples R China

3.Sichuan Acad Agr Sci, Biotechnol & Nucl Technol Res Inst, Chengdu 610066, Peoples R China

关键词： Militarine; Pharmacological activities and efficacy; Physicochemical properties; Anabolism; Regulatory mechanisms

期刊名称：HELIYON （ 影响因子：4.0； 五年影响因子：4.1 ）

ISSN：

年卷期： 2024 年 10 卷 2 期

页码：

收录情况： SCI

摘要： Militarine is the lead member of secondary metabolites found in multiple medicinal plants of the orchid family. It acts as not only an important inhibitor on plant growth, but also functions as the quality marker for medicinal materials. In addition, Militarine has been shown to possess remarkably medicinal value, with a definite potential for finding widespread adoption of treating various diseases, including lung injury, brain nerve injury, cognitive impairment, aging, tumors, inflammation, peptic ulcers, and more. Thus, it can serve as a material carrier for pharmacophore upon, so much so that it probes as natural source of lead compounds in the research and development of medication. The study reported herein makes an overview on the physicochemical properties and pharmacological mechanisms of Militarine compounds, summarizes the biogenic pathways of Militarine and organically integrates the biological characteristics of Militarine with multiple omics techniques. Besides, this review also constructs a regulatory system for the biological accumulation of Militarine around its precursor compounds, characteristic gene elements, key enzymes, important metabolic products, and critical steps and links. Exceptionally, emphasis on the biosynthesis of Militarine under both abiotic and biotic stress, as well as an elaboration of the signaling pathways and critical regulatory mechanisms that govern the metabolic flow of Militarine have been represented accordingly in this paper. These findings are expected to provide reference schemes and theoretical foundations for acquiring high-quality resources of Militarine and advancing its large-scale industrial production, drug development, and clinical applications to comprehensively elucidate the biosynthetic and metabolic pathways.

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