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Analysis of Gene Expression in Bladder Cancer: Possible Involvement of Mitosis and Complement and Coagulation Cascades Signaling Pathway

文献类型： 外文期刊

作者： Liu, Ying 1 ; Xiong, Shenghua 2 ; Liu, Shiying 3 ; Chen, Jie 3 ; Yang, Hao 4 ; Liu, Gang 3 ; Li, Gengmi 1 ;

作者机构： 1.Sichuan Acad Agr Sci, Rice & Sorghum Res Inst, Minist Agr, Key Lab Southwest Rice Biol & Genet Breeding, 508 Yuanquan Rd, Deyang City, Peoples R China

2.Sichuan Prov Transportat Hall Hosp, Dept Anesthesia, Chengdu, Sichuan, Peoples R China

3.Gen Hosp Western Theater Command, Dept Med Lab, Chengdu, Sichuan, Peoples R China

4.Peoples Hosp Deyang City, Dept Med Lab, Deyang City, Peoples R China

关键词： bladder cancer; differentially expressed genes; protein-protein interaction network; regulatory network

期刊名称：JOURNAL OF COMPUTATIONAL BIOLOGY （ 影响因子：1.479； 五年影响因子：1.377 ）

ISSN： 1066-5277

年卷期：

页码：

收录情况： SCI

摘要： CENPF, and CENPO were enriched in Submodule 2. Moreover, miR-519d had high degree in the regulatory network and CENPO was predicted to be one target of miR-519d. The upregulated CENPK, CENPF, and CENPO, and downregulated A2M, F13A1, and GNG11 might contribute to the progression of BC. In addition, the downregulated miR-519d might lead to the development of BC by upregulating the expression of CENPO. However, future investigation of those findings should be needed.

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