您好，欢迎访问四川省农业科学院 机构知识库！

Comparative genome-wide DNA methylation analysis reveals epigenomic differences in response to heat-humidity stress in Bombyx mori

文献类型： 外文期刊

作者： Chen, Peng 1 ; Xiao, Wen-Fu 1 ; Pan, Min-Hui 1 ; Xiao, Jin-Shu 2 ; Feng, Yu-Jie 1 ; Dong, Zhan-Qi 1 ; Zou, Bang-Xing 2 ;

作者机构： 1.Southwest Univ, State Key Lab Silkworm Genome Biol, Key Lab Sericultural Biol & Genet Breeding, Minist Agr & Rural Affairs, Beibei 400715, Peoples R China

2.Sichuan Acad Agr Sci, Sericultural Res Inst, Nanchong 637000, Peoples R China

关键词： Bombyx mori; DNA methylation; Epigenetic regulation; Environmental signal; Heat stress

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：6.953； 五年影响因子：6.737 ）

ISSN： 0141-8130

年卷期： 2020 年 164 卷

页码：

收录情况： SCI

摘要： DNA methylation is an important epigenetic modification and has been shown to be involved in the response to abiotic stress. However, there are few studies on DNA methylation in insect response to environmental signals. In this study, we conducted a comprehensive comparative analysis of DNA methylation profiles between two silkworm strains with significantly different resistance to heat and humidity by whole-genome bisulfite sequencing (WGBS). We identified, in total, 2934 differentially methylated regions (DMRs) between RT_48h (resistant strain with high-temperature/humidity treatment for 48 h) and ST_48h (sensitive strain with high-temperature/humidity treatment for 48 h) under cytosine context (CG), which corresponded to 1230 DMR-related genes (DMGs), and the DMRs were primarily located in the gene body (exon and intron) region. Gene ontology (GO) and KEGG analysis showed that these DMGs were most significantly enriched in binding, cellular metabolic process, and RNA transport pathways. Moreover, 10 DMGs have been revealed to be involved in the heat-humidity stress response in the silkworm. The results of this study indicated that DNA methylation plays crucial roles in silkworm response to environmental stressors and provides important clues to identify key resistance genes in silkworm under high-temperature/humidity stress response. (C) 2020 Elsevier B.V. All rights reserved.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：四川省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台