The Effects of Interventions with Glucosinolates and Their Metabolites in Cruciferous Vegetables on Inflammatory Bowel Disease: A Review
文献类型： 外文期刊
作者： Zhao, Jichun 1 ; Zhang, Xiaoqin 1 ; Li, Fuhua 1 ; Lei, Xiaojuan 1 ; Ge, Lihong 4 ; Li, Honghai 1 ; Zhao, Nan 5 ; Ming, Jian 1 ;
作者机构： 1.Southwest Univ, Coll Food Sci, Chongqing 400715, Peoples R China
2.Chongqing Key Lab Special Food Co Built Sichuan &, Chongqing 400715, Peoples R China
3.Southwest Univ, Res Ctr Fruits & Vegetables Logist Preservat & Nut, Chongqing 400715, Peoples R China
4.Sichuan Normal Univ, Coll Life Sci, Chengdu 610101, Peoples R China
5.Sichuan Acad Agr Sci, Inst Agroprod Proc Sci & Technol, Chengdu 610066, Peoples R China
关键词： IBD; glucosinolates; cruciferous vegetables; gut microbiota; antioxidant; anti-inflammatory
期刊名称：FOODS （ 影响因子：5.1； 五年影响因子：5.6 ）
ISSN：
年卷期： 2024 年 13 卷 21 期
页码：
收录情况： SCI
摘要： Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the gastrointestinal tract which affects millions of individuals worldwide. Despite advancements in treatment options, there is increasing interest in exploring natural interventions with minimal side effects. Cruciferous vegetables, such as broccoli, cabbage, and radishes, contain bioactive compounds known as glucosinolates (GLSs), which have shown promising effects in alleviating IBD symptoms. This review aims to provide a comprehensive overview of the physiological functions and mechanisms of cruciferous GLSs and their metabolites in the context of IBD. Reviewed studies demonstrated that GLSs attenuated all aspects of IBD, including regulating the intestinal microbiota composition, exerting antioxidant and anti-inflammatory effects, restoring intestinal barrier function, and regulating epigenetic mechanisms. In addition, a few interventions with GLS supplementation in clinical studies were also discussed. However, there are still several challenges and remaining knowledge gaps, including variations in animals' experimental outcomes, the bioavailability of certain compounds, and few clinical trials to validate their effectiveness in human subjects. Addressing these issues will contribute to a better understanding of the therapeutic potential of cruciferous GLSs and their metabolites in the management of IBD.
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