FeCl3-Catalyzed Stereoselective Construction of Spirooxindole Tetrahydroquinolines via Tandem 1,5-Hydride Transfer/Ring Closure
文献类型： 外文期刊
作者： Han, Yan-Yan 2 ; Han, Wen-Yong 1 ; Hou, Xue 1 ; Zhang, Xiao-Mei 1 ; Yuan, Wei-Cheng 1 ;
作者机构： 1.Chinese Acad Sci, Natl Engn Res Ctr Chiral Drugs, Chengdu Inst Organ Chem, Chengdu 610041, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Sichuan Acad Agr Sci, Ctr Anal & Testing, Chengdu 610066, Peoples R China
期刊名称：ORGANIC LETTERS （ 影响因子：6.005； 五年影响因子：5.551 ）
ISSN： 1523-7060
年卷期： 2012 年 14 卷 16 期
页码：
收录情况： SCI
摘要： An efficient FeCl3-catalyzed stereoselective intramolecular tandem 1,5-hydride transfer/ring closure reaction was developed. The method allows for the formation of structurally diverse spirooxindole tetrahydroquinolines in high yields (up to 98%) with good to excellent levels of diastereoselectivity (up to 99:1 dr). The catalytic enantioselective variant of this process was also investigated preliminarily with a chiral BINOL-derived phosphoric acid.
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