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Therapeutic effect and mechanism of electroacupuncture at Zusanli on plasticity of interstitial cells of Cajal: a study of rat ileum

文献类型： 外文期刊

作者： Peng, Mei-fang 2 ; Li, Kun 1 ; Wang, Chao 1 ; Zhu, Xiao-yan 1 ; Yang, Zheng 3 ; Zhang, Guo-hu 4 ; Wang, Pei-hong 4 ; Wang 1 ;

作者机构： 1.Chengdu Gen Hosp, Chengdu Mil Area Command, PLA Med Ctr, Basic Lab, Chengdu 610083, Peoples R China

2.Sichuan Acad Agr Sci, Inst Biotechnol & Nucl Technol, Chengdu 610061, Peoples R China

3.Chengdu Med Coll, Dept Preclin Med, Chengdu 610500, Peoples R China

4.Chengdu Gen Hosp, Chengdu Mil Area Command, Ctr Gen Surg, Chengdu 610083, Peoples R China

关键词： Electroacupuncture;Plasticity;DOG1;Inflammatory mediators;c-Kit signaling

期刊名称：BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE （ 影响因子：3.659； 五年影响因子：3.767 ）

ISSN： 1472-6882

年卷期： 2014 年 14 卷

页码：

收录情况： SCI

摘要： Background: Electroacupuncture (EA) is one of the techniques of acupuncture and is believed to be an effective alternative and complementary treatment in many disorders. The aims of this study were to investigate the effects and mechanisms of EA at acupoint Zusanli (ST36) on the plasticity of interstitial cells of Cajal (ICCs) in partial bowel obstruction. Methods: A Sprague Dawley rat model of partial bowel obstruction was established and EA was conducted at Zusanli (ST36) and Yinglingquan (SP9) in test and control groups, respectively. Experiments were performed to study the effects and mechanisms of EA at Zusanli on intestinal myoelectric activity, distribution and alteration of ICCs, expression of inflammatory mediators, and c-Kit expression. Results: 1) EA at Zusanli somewhat improved slow wave amplitude and frequency in the partial obstruction rats. 2) EA at Zusanli significantly stimulated the recovery of ICC networks and numbers. 3) the pro-inflammatory mediator TNF-alpha and NO activity were significantly reduced after EA at Zusanli, However, no significant changes were observed in the anti-inflammatory mediator IL-10 activity. 4) EA at Zusanli re-expressed c-Kit protein. However, EA at the control acupoint, SP9, significantly improved slow wave frequency and amplitude, but had no effect on ICC or inflammatory mediators. Conclusions: We concluded that EA at Zusanli might have a therapeutic effect on ICC plasticity, and that this effect might be mediated via a decrease in pro-inflammatory mediators and through the c-Kit signaling pathway, but that the relationship between EA at different acupoints and myoelectric activity needs further study.

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