Probiotic Lactiplantibacillus plantarum N-1 could prevent ethylene glycol-induced kidney stones by regulating gut microbiota and enhancing intestinal barrier function
文献类型： 外文期刊
作者： Wei, Zhitao 1 ; Cui, Yaqian 2 ; Tian, Lei 2 ; Liu, Yu 1 ; Yu, Yang 3 ; Jin, Xi 1 ; Li, Hong 1 ; Wang, Kunjie 1 ; Sun, Qun 2 ;
作者机构： 1.Sichuan Univ, West China Hosp, Dept Urol, Inst Urol,Lab Reconstruct Urol, 37 Guo Xue Xiang, Chengdu 610041, Sichuan, Peoples R China
2.Sichuan Univ, Coll Life Sci, Minist Educ, Key Lab Bioresources & Ecoenvironm, 24 South Sect 1,Yihuan Rd, Chengdu 610065, Sichuan, Peoples R China
3.Sichuan Acad Agr Sci, Soil & Fertilizer Inst, Natl Local Joint Engn Lab Breeding & Cultivat Edi, Chengdu, Peoples R China
关键词： gut microbiota; hyperoxaluria; intestinal barrier; intestinal inflammation; kidney stones; Lactiplantibacillus plantarum N-1
期刊名称：FASEB JOURNAL （ 影响因子：5.192； 五年影响因子：5.956 ）
ISSN： 0892-6638
年卷期： 2021 年 35 卷 11 期
页码：
收录情况： SCI
摘要： Defective permeability barrier is considered to be an incentive of hyperuricemia, however, the link between them has not been proven. Here, we evaluated the potential preventive effects of Lactiplantibacillus plantarum N-1 (LPN1) on gut microbiota and intestinal barrier function in rats with hyperoxaluria-induced kidney stones. Male rats were supplied with 1% ethylene glycol (EG) dissolved in drinking water for 4 weeks to develop hyperoxaluria, and some of them were administered with LPN1 for 4 weeks before EG treatment as a preventive intervention. We found that EG not only resulted hyperoxaluria and kidney stone formation, but also promoted the intestinal inflammation, elevated intestinal permeability, and gut microbiota disorders. Supplementation of LPN1 inhibited the renal crystalline deposits through reducing urinary oxalic acid and renal osteopontin and CD44 expression and improved EG-induced intestinal inflammation and barrier function by decreasing the serum LPS and TLR4/NF-kappa B signaling and up-regulating tight junction Claudin-2 in the colon, as well as increasing the production of short-chain fatty acid (SCFAs) and the abundance of beneficial SCFAs-producing bacteria, mainly from the families of Lachnospiraceae and Ruminococcaceae. Probiotic LPN1 could prevent EG-induced hyperoxaluria by regulating gut microbiota and enhancing intestinal barrier function.
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