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Two Half-Sandwiched Ruthenium (II) Compounds Containing 5-Fluorouracil Derivatives: Synthesis and Study of DNA Intercalation

文献类型： 外文期刊

作者： Li, Zhao-Jun 1 ; Hou, Yong 1 ; Qin, Da-An 2 ; Jin, Zhi-Min 3 ; Hu, Mao-Lin 2 ;

作者机构： 1.Sichuan Acad Agr Sci, Inst Biotechnol & Nucle Technol, Chengdu, Peoples R China

2.Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou, Peoples R China

3.Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou, Zhejiang, Peoples R China

期刊名称：PLOS ONE （ 影响因子：3.24； 五年影响因子：3.788 ）

ISSN： 1932-6203

年卷期： 2015 年 10 卷 3 期

页码：

收录情况： SCI

摘要： Two novel coordination compounds of half-sandwiched ruthenium(II) containing 2-(5-fluorouracil)-yl-N-(pyridyl)-acetamide were synthesized, and their intercalation binding modes with calf thymus DNA were revealed by hyperchromism of ultraviolet-visible spectroscopy; the binding constants were determined according to a Langmuir adsorption equation that was deduced on the base of careful cyclic voltammetry measurements. The two compounds exhibited DNA intercalation binding activities with the binding constants of 1.13x10(6) M-1 and 5.35 x10(5) M-1, respectively.

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