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The Role of BmTMED6 in Female Reproduction in Silkworm, Bombyx mori

文献类型： 外文期刊

作者： Wang, Chunyang 1 ; Hu, Zunmei 1 ; Guo, Yu 1 ; Xiao, Wenfu 2 ; Zhang, Youhong 2 ; Zhou, Anlian 2 ; Chen, Ping 1 ;

作者机构： 1.Southwest Univ, Coll Sericulture Text & Biomass Sci, Chongqing 400715, Peoples R China

2.Sichuan Acad Agr Sci, Sericultural Res Inst, Nanchong 637000, Peoples R China

3.Southwest Univ, State Key Lab Silkworm Genome Biol, Chongqing 400715, Peoples R China

关键词： transmembrane emp24 domain (TMED); silkworm (Bombyx mori); female reproduction; dopamine D2-like receptor (Dop2R)

期刊名称：INSECTS （ 影响因子：3.0； 五年影响因子：3.1 ）

ISSN：

年卷期： 2024 年 15 卷 2 期

页码：

收录情况： SCI

摘要： Transmembrane emp24 domain (TMED) proteins have been extensively studied in mammalian embryonic development, immune regulation, and signal transduction. However, their role in insects, apart from Drosophila melanogaster, remains largely unexplored. Our previous study demonstrated the abundant expression of BmTMED6 across all stages and tissues of the silkworm. In this study, we investigate the function of BmTMED6 in reproduction. We observe significant differences in the expression of BmTMED6 between male and female silkworms, particularly in the head and fatboby, during the larval stage. Furthermore, qRT-PCR and WB analysis reveal substantial variation in BmTMED6 levels in the ovaries during pupal development, suggesting a potential association with silkworm female reproduction. We find that reducing TMED6 expression significantly decreases the number of eggs laid by female moths, leading to an accumulation of unlaid eggs in the abdomen. Moreover, downregulation of BmTMED6 leads to a decrease in the expression of BmDop2R1 and BmDop2R2, while overexpression of BmTMED6 in vitro has the opposite effect. These indicate that BmTMED6 plays a role in oviposition in female moths, potentially through the dopamine signaling pathway. This study provides a new regulatory mechanism for female reproduction in insects.

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