Microalgae-Based Fucoxanthin Attenuates Rheumatoid Arthritis by Targeting the JAK-STAT Signaling Pathway and Gut Microbiota
文献类型： 外文期刊
作者： Xu, Hui-Ying 1 ; Jiang, Meng-Ting 1 ; Yang, Yu-Feng 2 ; Huang, Yisha 1 ; Yang, Wei-Dong 1 ; Li, Hong-Ye 1 ; Wang, Xiang 1 ;
作者机构： 1.Jinan Univ, Guangdong Higher Educ Inst, Coll Life Sci & Technol, Key Lab Eutrophicat & Red Tide Prevent, Guangzhou 510632, Peoples R China
2.Sichuan Acad Agr Sci, Biotechnol & Nucl Technol Res Inst, Chengdu 610066, Peoples R China
3.Jinan Univ, Guangdong Higher Educ Inst, Coll Life Sci & Technol, MOE Key Lab Tumor Mol Biol,Inst Life & Hlth Engn, Guangzhou 510632, Peoples R China
4.Jinan Univ, Guangdong Higher Educ Inst, Coll Life Sci & Technol, Key Lab Funct Prot Res,Inst Life & Hlth Engn, Guangzhou 510632, Peoples R China
关键词： rheumatoid arthritis; fucoxanthin; anti-inflammatory; JAK-STAT signal pathway; gut microbes
期刊名称：JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY （ 影响因子：6.2； 五年影响因子：6.4 ）
ISSN： 0021-8561
年卷期： 2025 年 73 卷 19 期
页码：
收录情况： SCI
摘要： Fucoxanthin, an abundant carotenoid in marine algae, has garnered attention for its diverse health benefits, including anti-inflammatory and anticancer properties. Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation and damage. This study investigated the therapeutic potential of fucoxanthin extracted from Phaeodactylum tricornutum in collagen-induced RA. Our results demonstrated that fucoxanthin significantly alleviated RA symptoms, including weight loss, joint swelling, and decreased appetite. Histological analysis revealed that fucoxanthin mitigated synovial inflammation, cartilage damage, and bone erosion. Mechanistically, transcriptomic analysis and cell experiments indicated that fucoxanthin suppressed the JAK-STAT signaling pathway by downregulating the expression of inflammatory cytokines, such as IL-6 and IL-1 beta. Furthermore, metagenomic analysis suggested that fucoxanthin restored the altered gut microbiota composition associated with RA. These findings highlight the therapeutic potential of fucoxanthin from P. tricornutum in the management of RA by targeting multiple pathways, including inflammation and gut microbiota.
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