文献类型： 外文期刊
作者： Lin, Jue 1 ; Liu, Hongli 2 ; Huang, Xiaoli 2 ; Deng, Yongqiang 1 ;
作者机构： 1.Sichuan Acad Agr Sci, Fisheries Res Inst, Chengdu 611731, Sichuan, Peoples R China
2.Sichuan Agr Univ, Coll Anim Sci & Technol, Dept Aquaculture, Chengdu, Sichuan, Peoples R China
关键词： gill; Honokiol; liver; oxidative stress; toxicology
期刊名称：JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY （ 影响因子：3.2； 五年影响因子：3.3 ）
ISSN： 1095-6670
年卷期： 2024 年 38 卷 8 期
页码：
收录情况： SCI
摘要： The compound Honokiol, derived from the bark of Magnolia officinalis, possesses the ability to induce apoptosis and inhibit cellular damage caused by reactive oxygen species. The objective of this study was to investigate the toxicological and histopathological effects of Honokiol on zebrafish (Danio rerio) through conducting a semistatic acute toxicity test involving immersion in an Honokiol-containing solution. The results showed that the toxic effects of Honokiol on zebrafish were primarily manifested in the liver and gills. When exposed to 0.6 mg/L of Honokiol, it could lead to liver hemorrhage as well as swelling and necrosis of gill tissues, and high concentrations of Honokiol could trigger inflammatory responses. Additionally, research found that Honokiol could induce apoptosis in liver and gill tissues through the P53 pathway and possessed the ability to enhance antioxidation. The present findings significantly contribute to a more profound understanding of the toxic impact of Honokiol and its underlying mechanism, thereby providing a valuable reference for the future safe utilization of Honokiol and related pharmaceutical advancements. Honokiol exhibits toxicity in zebrafish gills and liver, causing hemorrhage, swelling, and necrosis at elevated concentrations. It induces apoptosis in hepatic and gill cells via P53 activation. While possessing antioxidant properties that enhance enzyme function, excessive honokiol may induce inflammation and cell death.image
- 相关文献
作者其他论文 更多>>
-
Early brain gene network alterations and growth disruptions in juvenile Chinese longsnout catfish (Leiocassis longirostris) induced by 17(3-estradiol and 17α-methyltestosterone
作者：Feng, Yang;Deng, Yongqiang;Zhao, Zhongmeng;Zhao, Han;Liu, Senyue;Zhang, Lu;Duan, Yuanliang;Huang, Zhipeng;Du, Jun;Li, Qiang;Zhou, Jian;Mou, Chengyan;Ye, Hua
关键词：17(3-estradiol; 17 alpha-methyltestosterone; Chinese longsnout catfish ( Leiocassis; Brain; Immediate early genes
-
Gene-metabolite correlations underpin the hepatic fibrosis and metabolic disruption induced by methyltestosterone in juvenile Chinese longsnout catfish (Leiocassis longirostris)
作者：Feng, Yang;Deng, Yongqiang;Li, Zhao;Zhao, Zhongmeng;Zhao, Han;Liu, Senyue;Zhang, Lu;Duan, Yuanliang;Huang, Zhipeng;Du, Jun;Li, Qiang;Zhou, Jian;Mou, Chengyan;Wei, Zheng
关键词：Methyltestosterone; Chinese longsnout catfish(Leiocassis longirostris); Liver toxicity; Fibrosis; Lipid metabolism disruption; Multi-omics integration
-
Non-targeted metabolomics revealed the effect of starvation to juvenile Onychostoma sima liver
作者：Chen, Chunna;Huang, Yingying;Li, Shengxuan;Li, Zhengyi;Xu, Fei;Zhou, Bo;Lin, Jue;Chen, Chunna
关键词：Starvation;
Onychostoma sima ; Liver; Non-targeted metabolomics -
RNA-Seq Revealed the Effects of Cold Stress on Different Brain Regions of Leiocassis longirostris
作者：Liu, Senyue;Li, Qiang;Deng, Yongqiang;Feng, Yang;Zhao, Zhongmeng;Zhao, Han;Zhang, Lu;Duan, Yuanliang;Huang, Zhipeng;Zhou, Jian;Mou, Chengyan;Wang, Zhongwei
关键词：cold stress; brain;
Leiocassis longirostris ; rhythm; immunity; transcription -
Identification, Characterization, and Expression Analysis of CD79A and CD79B in the Sichuan Taimen (Hucho bleekeri)
作者：Chen, Yeyu;Yang, Huanchao;Wu, Xiaoyun;Liu, Zhao;Chen, Yanling;Wei, Qinyao;Lin, Jue;Yu, Yi;Tu, Quanyu;Li, Hua;Chen, Yeyu;Yang, Huanchao;Wu, Xiaoyun;Liu, Zhao;Chen, Yanling;Lin, Jue;Yu, Yi;Tu, Quanyu;Li, Hua;Wei, Qinyao
关键词：
-
The potential mechanism of concentrated mannan-oligosaccharide promoting goldfish's (Carassius auratus Linnaeus) resistance to Ichthyophthirius multifiliis invasion
作者：Liu, Senyue;Xu, Ming;Chen, Baipeng;Li, Fulong;Chen, Defang;Huang, Xiaoli;Deng, Yongqiang;Zhang, Yufan;Lin, Gang;Geng, Yi;Ou, Yangping
关键词：Mannan-oligosaccharide; Ichthyophthirius multifiliis; Mannose receptor; Phagocytosis; Macrophages; Immune
-
Identification of TonB-dependent siderophore receptor inhibitors against Flavobacterium columnare using a structure-based high-throughput virtual screening method
作者：Li, Minghao;Deng, Yongqiang;Li, Minghao;Chen, Baipeng;Xu, Ming;Li, Fulong;Chen, Defang;Huang, Xiaoli;Geng, Yi;Ouyang, Ping
关键词：Flavobacterium columnare; TonB dependent siderophore receptor; virtual screening; exoxolone; prokaryotic transcriptome
