文献类型： 外文期刊

作者： Zhang, Jinyi ¹ ; Niu, Po ¹ ; Li, Mingjie ² ; Wang, Yuan ² ; Ma, Yao ³ ; Wang, Pan ⁵ ;

作者机构： 1.Chongqing Three Gorges Univ, Sch Mech Engn, Chongqing 404100, Peoples R China

2.Shenzhen Hujia Technol Co Ltd, HBN Res Inst, Biol Lab, Shenzhen 518000, Peoples R China

3.Zhengzhou Univ, Sch Agr Sci, Zhengzhou 450001, Peoples R China

4.Henan Funiu Mt Biol & Ecol Environm Observ, Nanyang 474550, Peoples R China

5.Sichuan Acad Agr Machinery Sci, Chengdu 610066, Peoples R China

关键词： Cornus officinalis; secondary metabolite; alpha-glucosidase inhibitory activity; cholinesterase inhibitory activity; cytotoxicity

期刊名称：MOLECULES （ 影响因子：4.6； 五年影响因子：4.9 ）

ISSN：

年卷期： 2024 年 29 卷 7 期

页码：

收录情况： SCI

摘要： The fruits of Cornus officinalis are used not only as a popular health food to tonify the liver and kidney, but also as staple materials to treat dementia and other age-related diseases. The pharmacological function of C. officinalis fruits with or without seeds is controversial for treating some symptoms in a few herbal prescriptions. However, the related metabolite and pharmacological information between its pericarps and seeds are largely deficient. Here, comparative metabolomics analysis between C. officinalis pericarps and seeds were conducted using an ultra-performance liquid chromatography-electrospray ionization-tandem mass spectrometry, and therapeutic effects were also evaluated using several in vitro bioactivity arrays (antioxidant activity, alpha-glucosidase and cholinesterase inhibitory activities, and cell inhibitory properties). A total of 499 secondary metabolites were identified. Thereinto, 77 metabolites were determined as key differential metabolites between C. officinalis pericarps and seeds, and the flavonoid biosynthesis pathway was identified as the most significantly different pathway. Further, 47 metabolites were determined as potential bioactive constituents. In summary, C. officinalis seeds, which demonstrated higher contents in total phenolics, stronger in vitro antioxidant activities, better alpha-glucosidase and butyrylcholinesterase inhibitory activities, and stronger anticancer activities, exhibited considerable potential for food and health fields. This work provided insight into the metabolites and bioactivities of C. officinalis pericarps and seeds, contributing to their precise development and utilization.