Polysaccharide from Scutellaria baicalensis Georgi alleviates ulcerative colitis in mice by maintaining the intestinal barrier integrity via MLC/Notch signaling
文献类型： 外文期刊
作者： Xiao, Liang 1 ; Chen, Yongpo 2 ; Li, Xiaoqing 3 ; Li, Shuwei 4 ; Tang, Wenjie 4 ; Yan, Jiayou 4 ; Wei, Xiaolan 4 ; Zhou, Mengjia 4 ; Huang, Chongbo 4 ; Diao, Hui 4 ;
作者机构： 1.Hunan A Long Win Biotechnol Co Ltd, Changsha 410014, Hunan, Peoples R China
2.Sichuan Chelota Biotech Co Ltd, Deyang 618302, Sichuan, Peoples R China
3.Agr & Rural Affairs Xiangdong Dist, Pingxiang 337016, Jiangxi, Peoples R China
4.Sichuan Acad Anim Sci, Anim Breeding & Genet Key Lab Sichuan Prov, Chengdu 610066, Sichuan, Peoples R China
5.Sichuan Animtech Biol Dev Co Ltd, Chengdu 611330, Sichuan, Peoples R China
6.Sichuan Animtech Grp Co Ltd, Livestock & Poultry Biol Prod Key Lab Sichuan Prov, Chengdu 610066, Sichuan, Peoples R China
关键词： ulcerative colitis; Scutellaria baicalensis Georgi; polysaccharides; intestinal barrier; notch; myosin
期刊名称：CANADIAN JOURNAL OF ANIMAL SCIENCE （ 影响因子：1.0； 五年影响因子：1.3 ）
ISSN： 0008-3984
年卷期： 2025 年 105 卷
页码：
收录情况： SCI
摘要： Ulcerative colitis is a chronic idiopathic inflammatory bowel disease (IBD) that seriously impacts human health. So far, little information has been reported on the possible benefits of polysaccharides from Scutellaria baicalensis Georgi (SBGP) in alleviating colitis. Therefore, our study investigated the potential therapeutic effects of SBGP on mice with DSS-induced colitis. Results showed that SBGP administration ameliorated the severity of clinical symptoms and enhanced immunomodulatory effects in dextran sulfate sodium (DSS)-treated mice. Additionally, SBGP was found to regulate the inflammatory response, improve mucosal barrier integrity, and maintain tight junctions in the colonic epithelium. Furthermore, SBGP was found to restrain the activation of Notch and MLCK/MLC signaling pathways, which play important roles in inflammation and epithelial barrier homeostasis. These findings suggest that SBGP may have therapeutic potential for the treatment of colitis and other IBD.
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关键词：Isoleucine; Muscle; Extracellular matrix component; Extracellular matrix synthesis; Extracellular matrix degradation; Grass carp (Ctenopharyngodon idella)
