Protein chip of Boletus speciosus Frost Polysaccharide Revealed the Molecular Mechanism of Antitumor and Immunostimulatory Activities on Macrophages
文献类型： 外文期刊
作者： Su, Siyuan 1 ; Wang, Meng 2 ; Ding, Xiang 1 ; Hou, Yiling 1 ; Tang, Jie 3 ; Liu, Lu 1 ; Dong, Mingming 1 ; Jing, Ling 1 ;
作者机构： 1.China West Normal Univ, Coll Life Sci, Minist Educ, Key Lab Southwest China Wildlife Resources Conser, Nanchong 637009, Peoples R China
2.Zhengzhou Univ, Childrens Hosp, Dept Emergency Med, Zhengzhou 450000, Henan, Peoples R China
3.Sichuan Acad Agr Sci, Chengdu 610000, Sichuan, Peoples R China
关键词： Boletus speciosus Frost; polysaccharide; protein chip; macrophages
期刊名称：INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES （ 影响因子：0.975； 五年影响因子：1.18 ）
ISSN： 0250-474X
年卷期： 2018 年 80 卷 6 期
页码：
收录情况： SCI
摘要： The polysaccharide of Boletus speciosus Frost has a backbone of (1 -> 4)-alpha-L-mannopyranose residues, which branched at O-6 and the branches mainly comprised of (a -> 1)-alpha-D-galactopyranose residue. To find out signalling transduction pathways that mediate the effect of the polysaccharide of Boletus speciosus Frost on macrophages, the polysaccharide of Boletus speciosus Frost was used to stimulate the macrophages and 200 cytokines were detected with the help of a protein chip. Further analysis of the result revealed 48 up-regulated and 73 down-regulated cytokines. All cytokines were imported into the KEGG pathway database and NCBI to identify the signalling pathway and biological functions involved, respectively. The results showed that the cytokines fulfilled valuable functions in the JAK-STAT signalling pathway and NF-kappa B signalling pathway. This study thus revealed that the edible fungus polysaccharides could stimulate immune cells to secrete immune factors, which could provide a scientific basis for targeting sugar immunization preparations.
- 相关文献
作者其他论文 更多>>
-
Dynamic transcriptome analysis unravels key regulatory genes of maize root growth and development in response to potassium deficiency
作者：Guo, Song;Zhou, Zijun;He, Mingjiang;Qin, Yusheng;Liu, Zhigang;Sheng, Huajin;Olukayode, Toluwase;Kochian, Leon;Liu, Yonghong;Wang, Meng
关键词：Differentially expressed genes; Hub genes; Potassium deficiency; Root system architecture; Weighted gene co-expression network
-
Structure elucidation, immunomodulatory activity, antitumor activity and its molecular mechanism of a novel polysaccharide from Boletus reticulatus Schaeff
作者：Su, Siyuan;Hou, Yiling;Su, Siyuan;Liu, Binbin;Du, Zhouhe;Liu, Junfeng;Ding, Xiang
关键词：Boletus reticulatus Schaeff; Polysaccharides; Structure identification; Immunomodulatory activity; Antitumor activity
-
Large-scale commercial cultivation of morels: current state and perspectives
作者：Xu, Yingyin;Tang, Jie;Wang, Yong;He, Xiaolan;Tan, Hao;Yu, Yang;Chen, Ying;Peng, Weihong;Xu, Yingyin;Tang, Jie;Wang, Yong;He, Xiaolan;Tan, Hao;Yu, Yang;Chen, Ying;Peng, Weihong;Xu, Yingyin;Tang, Jie;Wang, Yong;He, Xiaolan;Tan, Hao;Yu, Yang;Chen, Ying;Peng, Weihong;Xu, Yingyin;Tang, Jie;Wang, Yong;He, Xiaolan;Tan, Hao;Yu, Yang;Chen, Ying;Peng, Weihong
关键词：Morel mushrooms; Commercial cultivation; Key technology; Unstable yield
-
Application of the mushroom volatile 1-octen-3-ol to suppress a morel disease caused by Paecilomyces penicillatus
作者：Yu, Yang;Liu, Tianhai;Liu, Lixu;Chen, Ying;Tang, Jie;Peng, Weihong;Tan, Hao;Yu, Yang;Liu, Tianhai;Liu, Lixu;Chen, Ying;Tang, Jie;Peng, Weihong;Tan, Hao;Tan, Hao
关键词：Morchella; Fructification failure; 1-Octen-3-ol; Disease suppression; Soil microbial diversity
-
Wheat genomic study for genetic improvement of traits in China
作者：Guo, Zifeng;Chong, Kang;Lu, Zefu;Gao, Lifeng;Zhao, Guangyao;Cao, Shuanghe;Zhang, Xueyong;He, Zhonghu;Jia, Jizeng;Xiao, Jun;Zhang, Aimin;Lu, Fei;Lin, Xuelei;Han, Fangpu;Fu, Xiangdong;Ling, Hong-Qing;Tong, Yiping;Liu, Zhiyong;Yao, Yingyin;Ni, Zhongfu;Chen, Qian;Hu, Zhaorong;Guo, Weilong;Yao, Yingyin;Ni, Zhongfu;Chen, Qian;Hu, Zhaorong;Guo, Weilong;Yao, Yingyin;Ni, Zhongfu;Chen, Qian;Hu, Zhaorong;Guo, Weilong;Wang, Mengcheng;Xia, Guangmin;Kong, Lingrang;Sun, Silong;Ma, Xin;Jia, Haiyan;Li, Guoqiang;Ma, Zhengqiang;Jia, Haiyan;Li, Guoqiang;Ma, Zhengqiang;Liu, Bao;Zhang, Kunpu;Wang, Daowen;Zhang, Kunpu;Wang, Daowen;Xu, Shengbao;Ma, Wujun;Li, Junming;Yang, Wuyun;Jiao, Yuannian;Wang, Meng;Xiao, Jun;Zhang, Aimin;Lu, Fei;Han, Fangpu;Fu, Xiangdong;Ling, Hong-Qing;Tong, Yiping;Liu, Zhiyong;Chong, Kang;Xiao, Jun;Zhang, Aimin;Lu, Fei;Han, Fangpu;Fu, Xiangdong;Ling, Hong-Qing;Tong, Yiping;Liu, Zhiyong;Chong, Kang;He, Zhonghu
关键词：wheat; genomics; genetic improvement; China
-
Morel Production Related to Soil Microbial Diversity and Evenness
作者：Tan, Hao;Liu, Tianhai;Yu, Yang;Tang, Jie;Jiang, Lin;Peng, Weihong;Tan, Hao;Tan, Hao;Liu, Tianhai;Yu, Yang;Tang, Jie;Jiang, Lin;Peng, Weihong;Martin, Francis M.;Martin, Francis M.
关键词：large-scale farming; fructification; soil microbial diversity; community evenness; predominant fungi
-
Dual RNA-Seq Analysis of the Interaction Between Edible Fungus Morchella sextelata and Its Pathogenic Fungus Paecilomyces penicillatus Uncovers the Candidate Defense and Pathogenic Factors
作者：Yu, Yang;Tan, Hao;Liu, Tianhai;Liu, Lixu;Tang, Jie;Peng, Weihong;Yu, Yang;Tan, Hao;Liu, Tianhai;Liu, Lixu;Tang, Jie;Peng, Weihong;Tan, Hao
关键词：Morchella sextelata; Paecilomyces penicillatus; pathogenic factors; response; transcriptomics; CAZymes; laccase; tyrosinase
