您好，欢迎访问四川省农业科学院 机构知识库！

Dissemination and prevalence of plasmid-mediated high-level tigecycline resistance gene tet (X4)

文献类型： 外文期刊

作者： Zhang, Shaqiu 1 ; Wen, Jinfeng 1 ; Wang, Yuwei 4 ; Wang, Mingshu 1 ; Jia, Renyong 1 ; Chen, Shun 1 ; Liu, Mafeng 1 ; Zhu, Dekang 1 ; Zhao, Xinxin 1 ; Wu, Ying 1 ; Yang, Qiao 1 ; Huang, Juan 1 ; Ou, Xumin 1 ; Mao, Sai 1 ; Gao, Qun 1 ; Sun, Di 1 ; Tian, Bin 1 ; Cheng, Anchun 1 ;

作者机构： 1.Sichuan Agr Univ, Coll Vet Med, Avian Dis Res Ctr, Chengdu, Peoples R China

2.Sichuan Agr Univ, Inst Prevent Vet Med, Chengdu, Peoples R China

3.Sichuan Agr Univ, Key Lab Anim Dis & Human Hlth Sichuan Prov, Chengdu, Peoples R China

4.Mianyang Acad Agr Sci, Mianyang, Peoples R China

关键词： antibiotic resistant bacteria; tigecycline resistance gene; plasmid-mediated; tet(X4); transmission; one health

期刊名称：FRONTIERS IN MICROBIOLOGY （ 影响因子：6.064； 五年影响因子：6.843 ）

ISSN：

年卷期： 2022 年 13 卷

页码：

收录情况： SCI

摘要： With the large-scale use of antibiotics, antibiotic resistant bacteria (ARB) continue to rise, and antibiotic resistance genes (ARGs) are regarded as emerging environmental pollutants. The new tetracycline-class antibiotic, tigecycline is the last resort for treating multidrug-resistant (MDR) bacteria. Plasmid-mediated horizontal transfer enables the sharing of genetic information among different bacteria. The tigecycline resistance gene tet(X) threatens the efficacy of tigecycline, and the adjacent ISCR2 or IS26 are often detected upstream and downstream of the tet(X) gene, which may play a crucial driving role in the transmission of the tet(X) gene. Since the first discovery of the plasmid-mediated high-level tigecycline resistance gene tet(X4) in China in 2019, the tet(X) genes, especially tet(X4), have been reported within various reservoirs worldwide, such as ducks, geese, migratory birds, chickens, pigs, cattle, aquatic animals, agricultural field, meat, and humans. Further, our current researches also mentioned viruses as novel environmental reservoirs of antibiotic resistance, which will probably become a focus of studying the transmission of ARGs. Overall, this article mainly aims to discuss the current status of plasmid-mediated transmission of different tet(X) genes, in particular tet(X4), as environmental pollutants, which will risk to public health for the "One Health" concept.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：四川省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台