您好，欢迎访问四川省农业科学院 机构知识库！

Injection of D1 receptor antagonist SCH23390 into the periaqueductal gray attenuates morphine withdrawal symptoms in rats

文献类型： 外文期刊

作者： Liu, Qiaofeng 1 ; Du, Guizhi 2 ; Xiao, Rui 1 ; Liu, Yang 1 ; Cao, Kang 1 ; Du, Xiaoyu 1 ; Tang, Shan 1 ; Huang, Wenli 3 ; Wa 1 ;

作者机构： 1.Chengdu Med Coll, Sch Basic Med Sci, Chengdu, Sichuan, Peoples R China

2.Sichuan Univ, Dept Anesthesiol, West China Hosp, Chengdu, Sichuan, Peoples R China

3.Sichuan Acad Agr Sci, Biotechnol & Nucl Technol Res Inst, Chengdu, Sichuan, Peoples R China

关键词： Morphine withdrawal; Midbrain periaqueductal gray; CaMKII; p-ERK; CREB

期刊名称：NEUROSCIENCE LETTERS （ 影响因子：3.046； 五年影响因子：2.855 ）

ISSN： 0304-3940

年卷期： 2020 年 714 卷

页码：

收录情况： SCI

摘要： The aim of this study was to investigate the relationship of dopamine D1 receptor (D1R) and its downstream factors with morphine withdrawal symptoms in rats. Rats were injected intraperitoneally with morphine in a dose-escalating manner. The midbrain periaqueductal gray (PAG) area was microinjected with D1R antagonist SCH23390 or D1R agonist SKF38393. Rats were intraperitoneally injected with naloxone (4 mg/kg) after the last morphine injection, and the withdrawal response was observed. The D1R antagonist reduced the withdrawal response in morphine-exposed rats and decreased the expression of Ca2+/calmodulin-dependent protein kinase II (CaMKII), phosphorylated extracellular signal-regulated kinase (p-ERK) and cAMP response element-binding protein (CREB) in the PAG. However, the ability of SKF38393 to increase the withdrawal response was weak and limited. Taken together, the results suggest that D1R antagonist decreased the withdrawal response in morphineexposed rats by downregulating the downstream factors, CaMKII, p-ERK and CREB.

  • 相关文献
作者其他论文 更多>>
置顶
购物车
反馈

© 京ICP备09089781号-29 主办单位：四川省农业科学院

学术资源： 中国农业科学院 农业专业知识服务系统 农科联盟资源共建共享平台 中国农业科技文献与信息服务平台 中国农业期刊集成服务平台