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Injection of D1 receptor antagonist SCH23390 into the periaqueductal gray attenuates morphine withdrawal symptoms in rats

文献类型: 外文期刊

作者: Liu, Qiaofeng 1 ; Xiao, Rui 1 ; Liu, Yang 1 ; Cao, Kang 1 ; Du, Xiaoyu 1 ; Tang, Shan 1 ; Wang, Xin 1 ; Du, Guizhi 2 ; Huang, Wenli 3 ;

作者机构: 1.Chengdu Med Coll, Sch Basic Med Sci, Chengdu, Sichuan, Peoples R China

2.Sichuan Univ, Dept Anesthesiol, West China Hosp, Chengdu, Sichuan, Peoples R China

3.Sichuan Acad Agr Sci, Biotechnol & Nucl Technol Res Inst, Chengdu, Sichuan, Peoples R China

关键词: Morphine withdrawal; Midbrain periaqueductal gray; CaMKII; p-ERK; CREB

期刊名称: NEUROSCIENCE LETTERS

ISSN: 0304-3940

年卷期: 2020 年 714 卷

页码:

收录情况: SCI

摘要: The aim of this study was to investigate the relationship of dopamine D1 receptor (D1R) and its downstream factors with morphine withdrawal symptoms in rats. Rats were injected intraperitoneally with morphine in a dose-escalating manner. The midbrain periaqueductal gray (PAG) area was microinjected with D1R antagonist SCH23390 or D1R agonist SKF38393. Rats were intraperitoneally injected with naloxone (4 mg/kg) after the last morphine injection, and the withdrawal response was observed. The D1R antagonist reduced the withdrawal response in morphine-exposed rats and decreased the expression of Ca2+/calmodulin-dependent protein kinase II (CaMKII), phosphorylated extracellular signal-regulated kinase (p-ERK) and cAMP response element-binding protein (CREB) in the PAG. However, the ability of SKF38393 to increase the withdrawal response was weak and limited. Taken together, the results suggest that D1R antagonist decreased the withdrawal response in morphineexposed rats by downregulating the downstream factors, CaMKII, p-ERK and CREB.

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